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Nitrous oxide, a commonly used anesthetic, oxidizes and inactivates vitamin B 12 , thus inhibiting both of the vitamin B 12 -dependent enzymes, and can produce many of the clinical features of vitamin B 12 deficiency, such as megaloblastic anemia and neuropathy

If that inflammatory response is excessive, or if the skin is pushed too aggressively in a single session, the melanocytes respond by producing excess pigment