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10.1016/j.neuro.2023.06.006 53 GuptaG.Jia JiaT.Yee WoonL.Kumar ChellappanD.CandasamyM.DuaK

In the extrinsic pathway, death receptors such as FAS contain cysteine-rich extracellular domains that undergo SSG under oxidative conditions

Mechanisms of action Preclinical studies document: Anxiolytic effect without sedation in classical tests (elevated plus maze, open field, light-dark box) GABAergic system modulation : allosteric potentiation of GABA-A observed ex vivo Enkephalin increase (endogenous opioid peptide) and serotonergic modulation Immunomodulatory effects inherited from tuftsin: macrophage activation, T-helper modulation Behavioural models Anxiolysis is measured via time spent in open arms of the elevated plus maze (EPM), visit ratio of central zones of open field , and exit latency in light-dark box

When results fall in this borderline range, a methylmalonic acid test is recommended to confirm whether a functional deficiency exists