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After entering the cells, FA-AgNPs dissolved and released Ag + in response to intracellular glutathione, which exerts a series of anti-inflammatory functions, induces apoptosis in M1 macrophages, scavenges reactive oxygen species (ROS), and promotes polarization of M2 macrophages, targeted RA therapy via simultaneous M1 macrophage apoptosis and M1/M2 macrophages reprogramming (Yang et al., 2021)

Furthermore, stem cells may provide therapeutic benefits by reducing ROS accumulation and pyroptosis through their antioxidant capacity and promoting M1 to M2 macrophage polarization

Externalized PS induces thrombin generation via factor X activation

Pat lightly to aid in absorption