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In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis

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Head-to-Head: Mechanism Comparison These two compounds represent two fundamentally different theoretical approaches to obesity pharmacology and one of them has clinical proof while the other does not

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