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After a large amount of glutamine enters tumor cells, it is catabolized into glutamate and ammonia by GLS, and glutamate is catabolized by glutamate dehydrogenase or transaminase to provide a carbon source for the tricarboxylic acid cycle

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These results indicate that the skeletal muscle oxidative capacity was enhanced by an increase in intrinsic mitochondrial respiration more than an upregulation of mitochondrial content