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It is recommended that the sequence should contain 20% charged residues to increase its solubility

The takeaway from that table is the whole point of an honest comparison: the two rows with real strength each describe only one drug, the direct cagrilintide-vs-retatrutide row is empty, and the only cross-drug row is explicitly weak

Biochim Biophys Acta 994:180186 Clavreul N, Bachschmid MM, Hou X, Shi C, Idrizovic A, Ido Y, Pimentel D, Cohen RA (2006) S-glutathiolation of p21ras by peroxynitrite mediates endothelial insulin resistance caused by oxidized low-density lipoprotein

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