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And are they safe

Sexual function and depressive symptoms in young women with hypothyroidism receiving levothyroxine/liothyronine combination therapy: a pilot study

Other than that, there is also an abstract from the International Journal of Cosmetic Science that found Coptis Japonica Root Extract and its active component called berberine to show potent inhibition of triglyceride (aka fat) accumulation and subcutaneous preadipocytes (the cells that become later fat cells) differentiation meaning that Goldthread Extract might also be useful in slimming and anti-cellulite products

It aids in DNA repair , helping to undo cellular damage caused by chronic stress