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In acute liver injury, ammonia concentrations greater than 200 mol/L are associated with cerebral edema and a poor prognosis, 83 and it has been suggested that ammonia concentrations should be used as part of the evaluation of prognosis in acute liver failure

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therefore, they may attack RBCs, inducing membrane structure changes (erythrocyte shrinkage, membrane blebbing, and PS exposure) and, finally, eryptosis