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While paracellular transmigration involves passage through intercellular junctionsoften exacerbated by disrupted tight junctions under pathological conditionstranscellular transport is facilitated by various endocytic mechanisms, such as clathrin-mediated endocytosis, macropinocytosis, and lipid raft-dependent pathways 157,158,159,160,161

In rare cases, mild redness or soreness at the injection site may occur but typically resolves within a few hours