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When ERK is phosphorylated, it translocates to the nucleus and activates transcription factors like CREB (cAMP response element-binding protein), which in turn drives the expression of genes responsible for synaptic plasticity and memory formation

doi: 10.1146/annurev-ento-120811-153650 Anangi, Raveendra, Koshy, Shyny, Huq, Redwan, Beeton, Christine, Chuang, Woei-Jer and King, Glenn F

Amphetamines disrupt VMAT2 function and vesicular uptake through a combination of mechanisms: The Weak Base Effect (pH Gradient Collapse) : Amphetamines are lipophilic weak bases (pKa of 9.9) that can readily diffuse across both the plasma and vesicular membranes to accumulate inside synaptic vesicles (Wimalasena 2011)

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