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What specific benefits have preclinical studies observed for each compound in models of metabolic disease

Various transporter-mediated or receptor-mediated transporting processes at the BBB responsible for endogenous molecules, such as transferrin, insulin, low density lipoprotein (LDL), glucose, glutathione, etc., have been targeted for developing brain targeting agents

However, it is unsafe for pregnant or breastfeeding women, as it can cause serious congenital disabilities and developmental issues in babies