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In addition, a colony replating assay and sphere formation assay showed a decreased ability to repopulate colonies and form spheres even long after the treatments have been removed, reducing their intrinsic stem cell capabilities

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In mice, a high-Se diet increased TCR signaling in CD4 + T cells, increased IL-2 expression, shifted the Th1/Th2 balance toward a Th1 phenotype, higher levels of interferon- (IFN-) and CD40 ligand (60)