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Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate

This relationship has been verified in the reverse as well: gallstone patients have been found to be more likely to have low serum iron levels than healthy individuals (Prasad 2015)