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GCLC-KO mice showed activation of C1q, which triggers engulfment of neurons by microglia, and disease-associated-microglia (DAM), suggesting that activation of microglia is linked to the neuronal loss

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This can reveal the changes in immune phenotypes and signaling pathways in different regions of the tumor after NP treatment, directly verifying whether its multi-target effects exert a synergistic anti-tumor effect through the immune system

Cardiac fibrosis assessed by late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) is positively correlated to ventricular tachyarrythmias and SCD in various cardiomyopathies 5,6,7