However, this process is not instant
Cascone T, William Jr WN, Weissferdt A, Leung CH, Federico L, Haymaker C, Bernatchez C Fossella FV, Mott FE, Papadimitrakopoulou V, Byers LA, Lam VK, Godoy M, Carter B, Lee JJ, Vaporciyan A, Gibbons DL, Swisher SG , Heymach JV, Sepesi B
In a rat model, our previous research on early NHPN-1010 treatment for blast-induced tinnitusspecifically targeting cochlear synaptopathydemonstrated that (1) blast overpressure caused a permanent loss of cochlear nerve ribbon synapses (RSs), and (2) administration of NHPN-1010 within 3 days of blast trauma, compared to placebo, significantly rescued RSs, as evidenced by ribbon counts in cochlear histological analyses and corresponding functional changes in suprathreshold wave-I amplitudes of the auditory brainstem response (ABR) 34
8 , 040902 (2020) Liu, A.-J., Xu, F., Han, S.-D., Pan, J., Wang, G.-M.: Mixed-ligand strategy for the construction of photochromic metalorganic frameworks driven by electron-transfer between nonphotoactive units