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The combined therapy of ADA with MTX was compared against the mono therapies of ADA and MTX, based on DAS28(CRP) remission rates, ACR20/50/70 response rates [54], and against placebo too in randomized control trial settings (RCTs) [55] and disclosed significant efficacy and improvement in the above-stated parameters [56]

Perhaps most remarkably, the healing achieved with BPC-157 was comparable to that seen with bone marrow grafts and autologous cortical bone implantation, which are considered gold standard treatments for segmental bone defects