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Guthikonda, Vasumathi T

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Another mode of GSH depletion occurs through GSH transferase-mediated reactions where DEM, an electrophilic reagent and a mildly reactive alpha, unsaturated carbonyl compound conjugates with GSH which is catalyzed by GSH transferase which leads to the formation of hydrophilic GSH conjugates and causes rapid depletion of GSH [11, 92, 27] [90]

Glutathione does not alter tirzepatide's half-life (approximately five days), absorption rate, or receptor binding affinity