glutathione reactive oxygen species Increased production during reductive stress: The roles of mitochondrial and thioredoxin reductases The ascorbate–glutathione cycle coming of

Copper (cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPAR pathways

Integrative Interventions Include: Diosmin

Indications include: Medically refractory disease not responding to optimized biologic therapy Bowel obstruction from fibrostenotic stricture Intra-abdominal abscess not amenable to percutaneous drainage Complex perianal fistula (seton placement, diversion) Enterocutaneous or enterovesical fistula Dysplasia or cancer in Crohns colitis Free perforation (rare) Nutritional Therapy Exclusive enteral nutrition (EEN) effective for induction in pediatric Crohns

Store it in a cool, dry place after opening