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In addition, DFX does not enter the brain, making it unsuitable for neurodegenerative applications

In a phase I trial of CB-839 in relapsed leukemia, patients receiving CB-839 treatment usually showed grade 1 or 2 toxicities like transaminitis, thrombocytopenia, gastrointestinal events, and fatigue and about 1/3 (9/26) patients showed grade 3 or 4 toxicities like hematologic cytopenia [63]

If laboratory results indicate a deficiency, we can tailor a treatment plan that may include B12 injections as part of your personalized care

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