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4 From mechanisms to applications: translational considerations for TME-oriented nanoplatforms The strategies discussed in previous sections are grounded in mechanistic insights and preclinical models

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CTLA4, a critical regulator of T-cell activation, is upregulated on CD4+ and CD8+ T cells in endometriosis, with elevated soluble CTLA4 (sCTLA4) in serum and peritoneal fluid of late-stage and infertility-associated cases