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A recent study on human intestinal organoids confirmed the downregulation of several genes responsible for ATP synthesis, assembly of mitochondrial complex I proteins and mitochondrial uncoupling proteins during 5-FU administration leading to overall mitochondrial dysfunction (Rodrigues et al

This situation may lead to SPT even in non-prolific sheep (Irmak et al., 2025)

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The affinity of SARS-CoV-2 for ACE2 receptors makes the virus prone to cause vascular infection that could explain atherosclerosis progression and arterial and venous thrombosis (270, 271)