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Based on the enhanced permeability and retention effect, the nanoparticles can accumulate in the tumorous tissue 33,34

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By binding to the GHRH receptor on the anterior pituitary, it initiates a release of growth hormone that preserves the natural negative feedback loops, preventing the saturation of receptors often seen with long-acting analogs

It has also been suggested a complex interplay between immune signaling and neuroactive steroids, since steroid hormones such as P4, E2, T, cortisol, DHEA, and 3-THP are key immunomodulators whose effects as pro- or anti-inflammatory often depend on their concentration (191194)