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Exploring the genetic underpinnings of these conditions may unveil critical insights into their co-occurrence and pave the way for more personalized and effective therapeutic approaches

Meanwhile, a meta-analysis of population-based studies found that individuals with high TMAO levels were more likely to develop hypertension compared with those with low TMAO levels (117)

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(135) demonstrated that metformin mixed with sorafenib promoted iron apoptosis via the p62-Keap1-Nrf2/HO1 signaling pathway, inhibiting the value-added of HCC cells