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Another double-blind RCT evaluating the administration of HA 120mg/d for 12 weeks reported a significant reduction in wrinkles and an increase in stratum corneum water content and skin elasticity and thickness.20 Similar results had been observed in earlier RCTs (Table 4)2123 and prospective studies.24 A study of the benefits of an oral eggshell supplement, which contains HA and collagen, showed an improvement in skin elasticity, a reduction in skin pigmentation, and very high patient satisfaction with facial softness, skin hydration, and hair and nail appearance.25 A double-blind RCT (n=88) with similar characteristics reported a reduction in periocular wrinkles and improved hair thickness and growth.26 Oral Tranexamic Acid The plasmin inhibitor tranexamic acid (TA) is a potent anti-inflammatory and depigmenting agent

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HGF/c-Met, EpCAM cross talk in PI3K/Akt/mTOR It is well established that the c-Met/PI3K/Akt signaling axis is crucial to regulate tumor cell critical functions, such as proliferation and survival