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The most common ototoxic drugs include pain medications, aminoglycoside antibiotics, chemotherapy drugs, blood pressure medications, antimalarial drugs, and antidepressants
The concept of trained immunity poses that long-term functional changes in innate immune cells can be induced by certain challenges, which are mediated by epigenetic reprogramming of innate immune cells and their stem/progenitor cells
Simultaneously, glutathione-S-transferase (GST) activity decreases by 72%, reducing the cellular capacity to clear toxic metabolites ( 3.3 Oxidative stress and mitochondrial dysfunction EED-induced oxidative stress represents a central mechanism underlying reproductive toxicity, with mitochondrial dysfunction serving as both cause and consequence of excessive reactive oxygen species production
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