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Our mechanistic investigations revealed that intracellular GSSG elevation sensitizes hepatocytes to TNF killing by inducing IKK--SSG formation, leading to suppressed NF-B activation

The inclusion of proper controls (negative and positive controls) as well as preventive/protective versus treatment (i.e., treatment with urolithin A before versus after exposure) of sleep disturbances and disorders designs should be considered to evaluate potential benefits of urolithin A in the prevention and management of sleep conditions and their downstream adverse health effects

This vitamin is excreted through bile, and is reabsorbed in the enterohepatic circulation