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Triglycerides values were not included for analysis since the measurements were confounded by sample hemolysis that interfered with the triglyceride reagent in the assay

Daily doses may be divided into multiple administrations if preferred (e.g., 125 mcg twice a day) to support tolerability or administration preferences

NNMT inhibitors display high membrane permeability Compounds spanning ~100-fold IC 50 values for NNMT inhibition were selected on the basis of positional substitutions around the N-methylated quinolinium scaffold[17] to obtain an estimate of drug-like oral absorption/bioavailability properties and guide the choice of inhibitors for in vitro and in vivo phenotypic studies

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