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A peer-reviewed study in the Journal of Endocrinology confirming that AOD9604 produces lipolysis and increases fat oxidation in obese mice via the beta-adrenergic pathway, with effects comparable to full-length HGH but without the insulin-disrupting side effects provided early mechanistic validation that informed the human trials

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It is normally obtained from an animal-based diet (Wolffenbuttel et al., 2024)

Specifically, the researchers suggested that the cleavage of caspase-3 and its substrate called Poly ADP-ribose polymerase (PARP) appeared markedly reduced, by ~43% and ~77% respectively, suggesting that the peptide complex may suppress this cascade of programmed cell death