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Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc

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When vitamin C donates electrons to neutralize free radicals, glutathione can restore vitamin C to its active form, and vitamin C can do the same for glutathione, creating a continuous antioxidant cycle

Tumour Biol 39:1010428317691429 Lpez de la Oliva AR, Campos-Sandoval JA, Gmez-Garca MC et al (2020) Nuclear translocation of glutaminase GLS2 in human cancer cells associates with proliferation arrest and differentiation