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Similarly, ERK (extracellular signal-regulated kinase) and its involvement in melanin synthesis via the ERK/CREB (cAMP response element binding protein) pathway demonstrate how kinases contribute not only to antioxidant defense but also to pigmentation regulation by upregulating MITF and TRP1 69,71

Here, we demonstrated that combining system x C blockade with APR-246 at relatively low doses, selectively and synergistically depleted mut-p53 cancer cells of GSH, leading to significant lipid peroxidation and induction of massive apoptosis (Fig

Hepatology 1999

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