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The International Federation of Gynecology and Obstetrics (FIGO) staging remains the single most important prognostic factor: five-year relative survival approaches 92% when disease is confined to the ovaries (stage I) but falls to 32% with distant metastasis (stage IV) [46, 47]

Furthermore, in the studies covering a stimulus and disease with organ-specific cytotoxicity, the significance of measuring organ-specific biomarkers greatly increases (Tajima et al., 2019

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