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Endogenous mRNAs present in these reticulocytes are destroyed by use of a nuclease, whose activity can be inhibited by the addition of Ca 2+

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Both medicines are administered as subcutaneous injections, typically once weekly, and are still undergoing large-scale clinical trials

MiADMSA treatment, by stripping the metals that serve as cofactors for the epigenetic eraser enzymes of the Tet and JmjC families, led to a wave of DNA and histone re-methylation at these loci, effectively silencing the resistance program at its root