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The trials tested oral, intravenous, and subcutaneous routes of administration at doses ranging from micrograms to 1 mg per day

In separate Phase 2 and Phase 3 trials, retatrutide at 12mg produced greater total body weight reduction than semaglutide at 2.4mg across comparable timeframes, with the difference primarily attributable to retatrutides additional glucagon receptor activation

It also activates pathways that encourage the cells responsible for repairing tissue to multiply and migrate to the site of injury, and it makes tendon tissue more responsive to the body's own growth hormone