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Regulates Overactive Immune Responses Many autoimmune diseases occur when the immune system becomes overactive and begins attacking healthy tissues

These are short synthetic peptide sequences from families studied in laboratory research, including a copper-binding tripeptide (GHK-Cu), a tripeptide fragment of alpha-melanocyte-stimulating hormone (KPV), and two peptide fragments (BPC-157 and TB-500)

Here, we show that a branched aliphatic amino acid or methionine at position 585 of albumin is required for optimal receptor binding, which cannot be replaced to prevent enzymatic cleavage without negatively affecting FcRn engagement

doi: 10.1136/annrheumdis-2019-216515 150 van VulpenLFDHolsteinKMartinoliC