The issue might be particularly concerning for the pediatric population with chronic illnesses, as this would lead to accelerated deterioration of the disease with micronutritional deficiencies, or conversely, slowing down the deterioration process [135]
Solvent A contained isopropanol/hexane/water (285:215:5, v/v/v), and solvent B contained isopropanol/hexane/water (285:215:40, v/v/v)
Effects lag the dose increase
Additionally, the same researchers later treated 4-month-old AD model mice by gavage daily for 5 months, with 25 mg/kg SF, which significantly reduced A plaque levels in the hippocampus and cerebral cortex, improved cognition, and was shown to reduce HDAC 1 and 3 levels, suggesting its potential to counteract A-induced cytotoxicity in AD models [232]