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Naunyn Schmiedebergs Arch Pharmacol 398(5):55695578

Frozen products can lose folate during storage due to oxidation, in contrast to canned products, which can lose more during the initial thermal treatment, but then are relatively stable because of the lack of oxygen 293

387 Notably, the CKD-FIX study and the PERL trials demonstrated that allopurinol did not significantly slow the deterioration of estimated glomerular filtration rate (eGFR) in chronic kidney disease patients compared to placebo, over a span of 2 and 3 years, respectively

This was observed in diverse population cohorts with multiple ethnic backgrounds, enhancing the generalizability of the results