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The single best reason to take a vitamin B12 supplement is to prevent vitamin B12 deficiency which can lead to a number of symptoms and even long-term health issues, such as chronic fatigue, mood disorders, neurodegenerative disorders, heart issues, anemia and neural tube defects in infants

In addition, ROS production and changes in mitochondrial membrane potential are associated with ferroptosis, so we examined the levels of intracellular ROS, as well as mitochondrial membrane potential changes

3.3 Strategies targeting downstream pathological consequences of oxidative stress Given that oxidative stress initiates and exacerbates a cascade of downstream pathological events, therapeutic strategies can also focus on interrupting these consequences, even if the primary oxidative insult is not fully neutralized