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Despite this, a substantial body of pre-clinical and limited clinical research has mapped DSIPs pharmacological effects across multiple systems, identifying several probable mechanistic axes including NMDA receptor modulation, adrenergic system regulation, MAPK/ERK cascade interaction, and mitochondrial respiration effects while acknowledging that the existence of an undiscovered DSIP-like endogenous peptide(s) may account for part of the DSIP-like immunoreactivity observed in tissue distribution studies

Yang et al., 2020)

Quick Answer: No human clinical trials have established a validated Dihexa dose, so all online dosing recommendations are extrapolations None of these sources is equivalent to a validated human clinical dose

Expert Insight / Pro Tip When designing experiments around a sermorelin ipamorelin dosage matrix, keep in mind that these two peptides degrade at slightly different rates when exposed to room temperature