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In the past years, several strategies directed at reducing the detrimental effects and amplifying the beneficial effects of astrocytes on neuroprotection and neurorestoration have been investigated 70,71

In this regard, elevated indicators for oxidative stress and lower levels of antioxidant enzymes were found in recurrent pterygia compared to primary pterygia [121]

Therefore, we assume that inactivation of the G20A mutant (and reduced activity by other GxGxxG mutants in this study) for vitamin K reduction could be due to a lack of enzyme binding to FAD and/or affecting the stability of the enzyme as previously reported 43