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Each dose tier delivered roughly 3 additional percentage points of weight loss, representing a linear dose-response relationship that holds across the full tested range

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A Phase 2 trial (NCT01311518) was designed to test RGN-352 in ~75 heart attack patients, but was placed on FDA clinical hold in 2011 due to manufacturing (GMP) compliance issues at the contract site not safety concerns with the drug itself

Additionally, a forearm brace placed just below the elbow reduces the forces on the tendon and relieves pain