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Currently, known immune cells present within AT include ATMs, T cells (CD4 + , CD8 + , Tregs), natural killer T cells, B cells, neutrophils, eosinophils, and dendritic and mast cells (130, 133, 134)

Therefore, GLS1 has been pointed out as a metabolic checkpoint, controlling cell survival via a coordination between glutamine and glucose [56]

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Compounds such as EGCG and apigenin promote apoptosis in melanoma cells by modulating pathways like MAPK and PI3K-AKT, while green tea polyphenols inhibit histone deacetylase (HDAC) and activate histone acetyltransferase (HAT), reactivating tumor-suppressor genes silenced during melanoma progression 138,148