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Notably, NS workers demonstrated stronger SARS-CoV-2-specific T-cell responses, and sleep metrics were not significantly associated with vaccine immunogenicity, suggesting that primary immune responses may be resilient to short-term sleep loss in healthy individuals 121

It is broken down by different enzymes and when the enzymes are not present or you may be suffering from an issue that makes it difficult to break down histamine, then histamine levels will build up and create a cascade of symptoms

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This network potentially maintains the disease course and shapes inflammation in the CNS, which is essential for initiating and dominating the progressive phase of MS