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Consequently, the GSH deprotonation step was considered non-rate-determining and thermodynamically favoured, leading us to use the GSH-thiolate as the starting point to compute the reaction mechanism for the conversion of flav-3-on-4-ol ( 7 ) into cyanidin ( 8-B4 ) in the wild-type enzyme and the C13S variant (Extended Data Fig

If results remain unexplained, particularly with very high levels, further investigation may include imaging or haematology referral depending on clinical context and associated abnormalities

Nitric oxide keeps your blood pressure level within a normal range by signaling blood vessel muscles to relax, expand and let blood through, while also preventing clots and plaque from forming