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By methylating and removing nicotinamide, NNMT effectively drains NAD+ precursor availability, leading to reduced intracellular NAD+ levels

doi: 10.1007/s11434-014-0722-7 Summary Keywords non-alcoholic liver disease, vitamin B12 concentrations, liver enzymes, Mendelian randomization, genome-wide association studies Citation Fu L, Wang Y and Hu Y-Q (2023) Bi-directional causal effect between vitamin B12 and non-alcoholic fatty liver disease: Inferring from large population data

Different mechanisms, different costs, different evidence bases

Its focused action on fat metabolism and repair functions highlights its promise in innovative therapeutic applications