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The injectables are bets placed on thin evidence with the explicit understanding that the evidence is thin

Mechanistically, metformin prolongs lifespan mainly by activating AMPK to inhibit the SASP

Supplementation of up to 2 grams methionine daily for long periods of time has not produced any serious side effects

The Subcutaneous Dosing Reality Now heres where things gets interesting The commonly cited research-use only dosages of 100250 mcg subcutaneously once daily for sleep optimization are based on case reports and observational studies, not on controlled trials that demonstrated the efficacy of DSIP Does this necessarily invalidate the subcutaneous use of DSIP