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Discussion 1) The study examined the effects of hyperthermic treatment at 43C on normal hematopoiesis derived from donor or remission bone marrow, as well as leukemic progenitor cells

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However, total tyrosyl phosphorylation (Figure S5A) and ERK phosphorylation (Figure S5B) were not altered in Tamoxifen resistant cell with Sorafenib treatment, suggesting that the effect of Sorafenib on cell growth is unlikely through inhibition of RTKs or RAF