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The ProMPT study was supported by the UK NIHR, Cancer Research UK and the MRC, and the Cambridge and Oxford Biomedical Research Centres

As a consequence, the main mitochondrial proteome (~1500 proteins) is encoded by the nucleus, translated in the cytosol and imported into the mitochondria through specific translocator complexes (TIM and TOM) of the inner mitochondrial membrane (IMM) and outer mitochondrial membrane (OMM), respectively