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Hsp60, Hsp70, and gp96 can enhance the expression of B7 and MHC-II on the surface of plasmacytoid dendritic cells (antigen presenting cells), stimulate dendritic cell maturation, migration to draining lymph nodes, and induce the secretion of chemokines by macrophages and plasmacytoid dendritic cells (DCs) (36)

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Genes regulating glycogen synthase kinase-3 (GSK-3), a pro-apoptotic (programed cell death) peptide and a functional opponent of proteins involved in neuronal plasticity development, differentiation, and cytoskeletal assembly, have also been implicated in bipolar etiology