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Some clinical trials have investigated glutathiones effects on skin pigmentation, and there is limited evidence that high-dose glutathione supplementation may reduce melanin production over time

Fibrinolytic activation and intravascular thrombosis can be measured by the amount of D-Dimer in the blood

Middle cerebral artery (MCA) occlusion, induced with aneurysm clips, was confirmed using 3D-Digital Subtraction Angiography, which was used to quantify the area at risk (AAR) of infarction, as well as tissue perfusion

At the end of the experiment, brains were collected for cresyl violet staining to confirm cannula placement