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The mechanism is well-characterized and scientifically sound NNMT overexpression in obese adipose tissue is well-documented, and its inhibition does restore metabolic function in cell culture and animal models

effective contraception is advised for women of childbearing potential Cost and access : NHS funding typically follows NICE technology appraisal criteria with specialist oversight and is usually limited to a maximum of 2 years Patients must be carefully selected and monitored to maximise benefits whilst minimising potential adverse effects

T2DM is predominantly found in adults

Mutagenesis 15 , 311316 (2000)